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KMID : 0861019970120020143
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Korea Journal of Herbology
1997 Volume.12 No. 2 p.143 ~ p.155
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Studies on the Antiallergic Effect of RADIX ASARI
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Abstract
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This study was investigated the inhibitory activity of RADIX ASARI (RA) on type I immediate hypersensitivity of the anaphylactic type. RA inhibited compound 48/80-induced anaphylaxis 100% with a dose of 0.5 g/㎏ body weigh at 1 h before or 5 and 10 min after injection of compound 48/80. RA also exhibited the dose-dependent inhibitory effect on compound 48/80-induced, Substance P-induced and anti-DNP IgE-induced histamine release from rat peritoneal mast cells. These results suggest the possibility that RA induced inhibition of type I allergic reaction is regulated by histamine.
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